Impact of the aging tumor microenvironment on immune checkpoint inhibitors therapy

VernacularTitle:老年肿瘤微环境对免疫检查点抑制剂治疗的影响
Author: Huicong ZHOU ¹ ; Yajuan SHAO
Author Information

1. 郑州大学第二附属医院消化内科,郑州河南 450014
Keywords: tumor microenvironment; extracellular matrix; aging; immune checkpoint inhibitors
From: Basic & Clinical Medicine 2025;45(9):1139-1143
CountryChina
Language:Chinese
Abstract: The role of tumor microenvironment(TME)in tumor genesis and progression has attracted increasing attention.This review describes the effects of aging on the function of immune cells,extra cellular matrix,vascula-ture,cytokines,and metabolites in the tumor microenvironment,which may alter the host's response to immune checkpoint inhibitors(ICIs)and relies on the results of the most recent clinical studies to evaluate the safety of ICIs for elderly oncology patients and potential adverse effects.