Advances in obesity promoting asthma exacerbations
10.16352/j.issn.1001-6325.2025.08.1103
- VernacularTitle:肥胖促进哮喘发作的研究进展
- Author:
Yunxuan XIANG
1
;
Xiaoyue CHANG
Author Information
1. 内蒙古医科大学包头临床医学院呼吸与危重症医学科,内蒙古包头 014040
- Keywords:
asthma;
obesity;
mechanisms;
treatment
- From:
Basic & Clinical Medicine
2025;45(8):1103-1107
- CountryChina
- Language:Chinese
-
Abstract:
Obesity can promote asthma exacerbations by a complex mechanism of action involving multi-system in-teractions such as mechanomechanics,inflammatory response,genetic inheritance,microbial composition and met-abolic syndrome.Obesity reduces the compliance of lung tissue and chest wall,increases airway resistance,leads to airway narrowing,and aggravates asthma symptoms.Obesity can increase the release of inflammatory factors and ag-gravate the airway inflammatory response in asthma.Obesity can increase the risk of asthma by genetically influen-cing the obesity phenotype.Obesity can affect the development of asthma by altering the composition of the microbi-ota.Obesity can also worsen asthma by causing a series of metabolic syndrome.In conclusion,the mechanisms asso-ciated with obesity-promoted asthma involve multi-system interactions.Targeted metabolic drugs and biologics also show great potential in the treatment of obesity-associated asthma.
