Role of protein tyrosine kinase-2 in gynecological tumors
10.16352/j.issn.1001-6325.2025.08.1098
- VernacularTitle:蛋白酪氨酸激酶-2在妇科肿瘤中的作用
- Author:
Yi QIN
1
;
Xiaoyan WANG
Author Information
1. 山西医科大学第二临床医学院妇产科,山西太原 030000
- Keywords:
malignant gynecological tumor;
focal adhesion kinase;
tumor metastasis;
signal pathway;
PTK2 inhibitor
- From:
Basic & Clinical Medicine
2025;45(8):1098-1102
- CountryChina
- Language:Chinese
-
Abstract:
Protein tyrosine kinase 2(PTK2)is an important non-receptor tyrosine kinase that functions through both kinase-dependent and kinase-independent pathways.PTK2 can activate the downstream pathways through inte-grin-mediated adhesion signal transduction,regulating tumor cell proliferation,migration and epithelial-mesenchymal transition(EMT).Additionally,PTK2 can also remodel the tumor microenvironment,promote tumor metastasis,angiogenesis and immune escape.A large number of studies have shown that PTK2 is highly expressed in various gynecological cancers,and its expression level is significantly associated with tumor stage,poor prognosis and clinical drug resistance.Therefore,PTK2 is expected to serve as a novel therapeutic target and prognostic bio-marker for gynecological malignancies in the future.
