The role of hypoxia-inducible factor-1α in the pathogenesis of sarcopenia
10.16352/j.issn.1001-6325.2025.08.1093
- VernacularTitle:低氧诱导因子-1α在肌肉减少症发病中作用机制
- Author:
Qihai ZHU
1
;
Yu ZHANG
Author Information
1. 新疆医科大学第五附属医院呼吸与危重症医学科,新疆乌鲁木齐 830000
- Keywords:
hypoxia inducible factor-1α;
sarcopenia;
pathogenesis
- From:
Basic & Clinical Medicine
2025;45(8):1093-1097
- CountryChina
- Language:Chinese
-
Abstract:
HIF-1α,a key transcription factor for cellular adaptation to hypoxia,plays a significant role in the devel-opment of sarcopenia.In the context of long-term chronic hypoxia,the expression level of HIF-1α is abnormal.It functions in the development of sarcopenia by regulating multiple signaling pathways,including iron metabolism,mitochondrial function,angiogenesis,remodeling of the extracellular matrix,and protein synthesis and metabolism.Moreover,the overactivation of HIF-1α may lead to dysfunction of satellite cells,thereby reducing the capacity for muscle regeneration and repair.
