Research progress of LSD1 in regulating tumor immune mechanisms
10.16352/j.issn.1001-6325.2025.08.1088
- VernacularTitle:LSD1调控肿瘤免疫机制的研究进展
- Author:
Lijuan LONG
1
;
Songze SONG
;
Qinong YE
;
Jing LIN
Author Information
1. 解放军总医院第四医学中心检验科,北京 100048
- Keywords:
LSD1;
tumor immunity;
immunotherapy;
tumor microenvironment;
immune checkpoint
- From:
Basic & Clinical Medicine
2025;45(8):1088-1092
- CountryChina
- Language:Chinese
-
Abstract:
Lysine-specific demethylase 1(LSD1)plays a regulatory role in tumor immunity.LSD1 affects CD8+T cell infiltration by regulating AGO2 protein level,and it is required for normal B cell proliferation and differentiation via reducing local chromatin accessibility.LSD1 inhibition promotes NK cell cytotoxicity of cancer cells through restoring the expression of ULBPs.LSD1 affects the resistance of M1 macrophages to oxidative stress by regulating the level of SOD2;In addition,regulating the expression of LSD1 affects the anti-tumor function of CD 19 CAR-T cells and immune checkpoint blockers.The development of drugs targeting LSD1 will provide new ideas for immunotherapy of tumors.
