Progress on omics studies of chronic thromboembolic pulmonary hypertension
10.16352/j.issn.1001-6325.2025.07.0963
- VernacularTitle:慢性血栓栓塞性肺动脉高压组学研究进展
- Author:
Wenxin DUAN
1
;
Wanlu SONG
;
Peiran YANG
;
Jing WANG
Author Information
1. 中国医学科学院 北京协和医学院,北京 100730
- Keywords:
chronic thromboembolic pulmonary hypertension(CTEPH);
single-cell transcriptomics;
genomics;
proteomics;
metabo-lomics
- From:
Basic & Clinical Medicine
2025;45(7):963-968
- CountryChina
- Language:Chinese
-
Abstract:
Chronic thromboembolic pulmonary hypertension(CTEPH)is a form of pulmonary hypertension caused by unresolved thrombi and chronic embolization in the pulmonary arteries.In recent years,multi-omics technologies have provided multidimensional insights into CTEPH.Single-cell transcriptomics has identified key pathogenic cell subsets and related mechanisms;Genomics has revealed susceptibility genes associated with coagulation;Proteomics has uncovered differentially expressed proteins closely linked to vascular remodeling;And metabolomics has characterized metabolic reprogramming features and potential sub-typing biomarkers.This review summarizes re-cent advances in these omics fields and discusses their value and prospects in mechanistic exploration,biomarker discovery,and personalized therapeutic strategies.
