Role of lactate dehydrogenase A in malignant hematological diseases
10.16352/j.issn.1001-6325.2025.07.0958
- VernacularTitle:乳酸脱氢酶A在恶性血液病中的作用
- Author:
Yuzhen MO
1
;
Tingting CHEN
;
Hebing ZHOU
Author Information
1. 首都医科大学附属北京潞河医院 血液科,北京 101199
- Keywords:
lactate dehydrogenase A;
malignant hematological disease;
glycolysis
- From:
Basic & Clinical Medicine
2025;45(7):958-962
- CountryChina
- Language:Chinese
-
Abstract:
Lactate dehydrogenase A(LDHA)is an important enzyme involved in the anaerobic glycolysis of cells,catalyzing the conversion of pyruvate to lactate and participating in processes such as tumor proliferation,mi-gration,invasion,and the regulation of the tumor microenvironment.High expression levels of LDHA are often in-dicative of disease progression and poor prognosis in malignant hematological diseases.The expression of LDHA in malignant hematological diseases is closely associated with various molecules,including HIF-1,microRNAs and c-Myc,as well as signaling pathways like PI3K/AKT/GSK3,USP1/PLK1/LDHA and Fbw7/LDHA/lactate/miR-223.Meanwhile,the progression of malignant hematological conditions facilitated by LDHA primarily occurs through the regulation of energy metabolism via glycolytic pathways.
