Role of nuclear poly(A)binding protein 1 in tumors

VernacularTitle:核多聚腺苷酸结合蛋白1在肿瘤中的作用
Author: Lizhou SHI ¹ ; Wei HAN ; Xiaojun SHEN
Author Information

1. 南京医科大学姑苏学院昆山市第一人民医院普外科,江苏昆山 215300
Keywords: nuclear poly(A)binding protein 1(PABPN1); alternative polyadenylation; tumor
From: Basic & Clinical Medicine 2025;45(6):822-828
CountryChina
Language:Chinese
Abstract: Nuclear polyadenosine-binding protein 1(PABPN1)is the only known polyadenosine-binding protein in the cell nucleus of mammals.The first attention was resulted from relevant research on oculopharyngeal muscular dystrophy(OPMD),where mutations and aggregation of PABPN1 were found to be the main pathogenesis of the disease.Recently,PABPN1 is found to be abnormally expressed in some tumor tissues,and confirmed to be in-volved in regulating selective polyadenylation,which leads to the occurrence and development of various human tumors.This article briefly introduces the structure and function of PABPN1,reviews progress of research related to PABPN1 and tumors in recent years,and provide our thought for exploring point potential pathways for future re-search on the role and mechanism of PABPN1 in the occurrence and development of tumors.