The impact of obstructive sleep apnea on the remodeling of the immune system and its clinical significance
10.16352/j.issn.1001-6325.2025.06.0816
- VernacularTitle:阻塞性睡眠呼吸暂停对机体免疫系统的重塑及其临床意义
- Author:
Jieqiong LI
1
;
Yi XIAO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科,北京 100730
- Keywords:
obstructive sleep apnea;
immune system;
clinical significance
- From:
Basic & Clinical Medicine
2025;45(6):816-821
- CountryChina
- Language:Chinese
-
Abstract:
Obstructive sleep apnea(OSA)is a multifactor respiratory disorder characterized by recurrent episodes of airway collapse,leading to intermittent hypoxemia,hypercapnia,and sleep fragmentation.Intermittent hypoxia(IH)has profound effects on various body systems,particularly the immune system.Additionally,the suppression of the related inflammatory molecules mitigates IH-induced inflammation and tissue injury,presenting new potential targets for treating OSA-related complications.This review aims to explore the mechanisms by which OSA reshapes the immune system and its clinical significance.
