Safety of sugammadex muscle relaxation reversal during spinal surgery with motor evoked potential monitoring
10.16352/j.issn.1001-6325.2025.06.0807
- VernacularTitle:脊柱手术中运动诱发电位监测期间使用舒更葡糖钠拮抗神经肌肉阻滞的安全性
- Author:
Bo MA
1
;
Minyu JIAN
;
Longnian JING
;
Chengwei WANG
;
Haiyang LIU
;
Ruquan HAN
Author Information
1. 首都医科大学附属北京天坛医院麻醉科,北京 100070
- Keywords:
spinal surgery;
neurological monitoring;
motor evoked potential;
sugammadex
- From:
Basic & Clinical Medicine
2025;45(6):807-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of sugammadex on safety indicators such as body movement,choking,peak airway pressure during spinal surgery with motor evoked potential monitoring.Methods This study was a ret-rospective analysis of two randomized controlled trials.Patients undergoing selective thoracic and lumbar spinal sur-gery with intraoperative motor evoked potential monitoring were included.Rocuronium was continuously infused and the train-of-four stimulation count was maintained at 2.When motor evoked potential monitoring started,stop rocu-ronium infusion and 2 mg/kg of sugammadex was given.Indicators were compared between administration of sugam-madex and 5,10,20,30,60 minutes after administration like body movement,choking,peak airway pressure,allergic reaction,mean arterial pressure,heart rate,end expiratory pressure of CO2 and the train-of-four stimulation ratio(TOFr).Results A total of 120 patients were finally included in the analysis.Before administering sugammadex,TOFr was 0.2.At 5,10,20,30 and 60 minutes after administration,TOFr were 0.8,0.8,0.9,0.9,0.9 respectively.No patient experienced intraoperative body movement,choking,or allergy reaction.Compared with the time of sugamma-dex administration,heart rate was significantly reduced 5,10,20,30 and 60 minutes after administration(P＜0.05),there was no significant change in the remaining indicators.Conclusions Sugammadex can be safely used during spinal surgery with motor evoked potential monitoring.
