Effect of ergothioneine on tissue metabolism in middle-aged and aged mice
10.16352/j.issn.1001-6325.2025.06.0709
- VernacularTitle:麦角硫因对中老年小鼠组织代谢的影响
- Author:
Haoran CHEN
1
;
Fang WANG
;
Yanni MA
;
Jia YU
;
Lin WANG
Author Information
1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 生物化学与分子生物学系重大疾病共性机制研究全国重点实验室,北京 100005
- Keywords:
ergothioneine;
middle-aged and aged mice;
metabolome;
metabolic pathways
- From:
Basic & Clinical Medicine
2025;45(6):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ergothioneine(EGT)on tissue metabolism in middle-aged and aged mice.Methods Nine-month-old middle-aged and aged C57BL/6J mice were selected to be gavaged with EGT aqueous solution at the dose and frequency of 35 mg EGT per kg body weight every two days.The control group was gavaged with the same amount of water.Both groups were fed with EGT-free diet.After 7 weeks,the liver,kidney,and small intestine of mice were collected,and untargeted metabolomics analysis was performed using ultra-per-formance liquid chromatography-mass spectrometry(UHPLC-MS).The differential metabolites were selected for KEGG metabolic pathway enrichment analysis.Results Compared with the control group,the abundances of me-tabolites related to redox balance in liver,kidney and small intestine of middle-aged and aged mice treated with EGT did not change significantly.However,taurine and hypotaurine metabolism in liver(P＜0.01),purine metabo-lism in kidney(P＜0.01),and cysteine and methionine metabolism in small intestine(P＜0.001)were affected.Conclusions Non-redox-related metabolic changes in the liver,kidney and small intestine of middle-aged and aged mice by ergothioheine.
