Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia
10.16352/j.issn.1001-6325.2025.05.0675
- VernacularTitle:多靶点CAR-T细胞疗法在急性B淋巴细胞白血病中的应用
- Author:
Jinjin CAO
1
;
Juan DU
;
Shanna QU
;
Mingyu ZHU
;
Yang WANG
;
Han HU
;
Binlei LIU
Author Information
1. 湖北工业大学生命科学与健康工程学院,湖北武汉 430068
- Keywords:
multi-target;
CAR-T cell therapy;
B-cell acute lymphoblastic leukemia;
off-target effect;
tumor-associated antigen
- From:
Basic & Clinical Medicine
2025;45(5):675-680
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor-modified T(CAR-T)cell therapy,as a new type of cellular immunotherapy,has shown good clinical efficacy in the treatment of malignant hematological tumors,especially B-cell acute lympho-blastic leukemia.However,there are problems such as antigen loss and immune evasion in single-target selection,so multi-target therapy strategies are gradually gaining attention.Multi-target CAR-T can effectively avoid antigen escape caused by a single target by targeting multiple tumor-associated antigens at the same time,reduce the risk of recurrence,and is expected to improve the therapeutic effect.This paper primarily discusses the structural types of multi-target CAR-T cell therapy and its clinical trial applications in the treatment of B-cell acute lymphoblastic leu-kemia(B-ALL),aiming to provide future references for the treatment of B-ALL.
