Research progress of performn 2
10.16352/j.issn.1001-6325.2025.04.0542
- VernacularTitle:穿孔素2的研究进展
- Author:
Zhiyuan DENG
1
;
Lu BAI
;
Rong YU
Author Information
1. 北京大学肿瘤医院内蒙古医院 内蒙古医科大学附属肿瘤医院放疗科,内蒙古呼和浩特 010020;内蒙古医科大学 研究生院,内蒙古呼和浩特 010110
- Keywords:
perforin 2;
MPEG 1;
membrane attack complex perforin;
poroprotein
- From:
Basic & Clinical Medicine
2025;45(4):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Perforin 2(MPEG 1)is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin)superfamily,which is mainly secreted by cytotoxic T lymphocytes,natural killer cells and mac-rophages Through the formation of active pores on the target cell membrane,perforin 2 participates in altering the permeability-pressure of the target cell,or collaborates with granzymes to induce the apoptosis of target cells.Re-cently,with the development of molecular biology,MPEG 1 has been increasingly studied,and the unique gene se-quence and cell types of perforin 2 have specific functions and adaptive evolution in different immune cells,which may determine its performance and therapeutic potential in different disease states.
