Acetylation modification and chronic obstructive pulmonary disease
10.16352/j.issn.1001-6325.2025.04.0536
- VernacularTitle:乙酰化修饰与慢性阻塞性肺疾病
- Author:
Pei WANG
1
;
Tao BIAN
;
Yan WU
Author Information
1. 南京医科大学附属无锡临床医学院 呼吸内科,江苏无锡 214000
- Keywords:
acetylation;
chronic obstructive pulmonary disease;
inflammatory reaction;
oxidative stress
- From:
Basic & Clinical Medicine
2025;45(4):536-541
- CountryChina
- Language:Chinese
-
Abstract:
The main features of chronic obstructive pulmonary disease include chronic airway inflammation,persis-tent airflow limitation,progressive dyspnea,and impaired lung function.Acetylation is one of the most common post-translational modifications of proteins,which plays an important role in the pathogenesis of chronic obstructive pulmonary disease,such as oxidative stress,inflammatory reaction,and airway remodeling,by regulating gene ex-pression,cell signaling,and protein function.Therefore,exploring the regulatory mechanism of acetylating modifi-cation in chronic obstructive pulmonary disease can not only deeply understand the pathophysiological mechanism of the disease,but also provide a theoretical basis for the development of new treatment strategies.
