Correlation of oncogene c-MYC expression with mitochondrial metabolic enzyme DLAT/DLST and progression of pancreatic ductal adenocarcinoma
10.16352/j.issn.1001-6325.2025.04.0450
- VernacularTitle:癌基因c-MYC表达与线粒体代谢酶DLAT/DLST及胰腺导管腺癌进展相关
- Author:
Yeting XU
1
;
Ziyi QIN
;
Yucheng WANG
;
Huanwen WU
;
Rui JU
;
Lei GUO
Author Information
1. 中国医学科学院基础医学研究所北京协和医学院基础学院药理系,北京 100005
- Keywords:
pancreatic cancer;
c-MYC;
mitochondrial metabolism
- From:
Basic & Clinical Medicine
2025;45(4):450-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between c-MYC expression and mitochondrial metabolism in malignant duct epithelial cells of pancreatic cancer patients.Methods GEPIA database was used to analyze the correlation between c-MYC expression and overall survival.The expression of c-MYC in tumor tissues was detected by immunohistochemical staining.The difference of DLAT and DLST gene expression between tumor and normal tis-sues was compared in GEPIA database.HP A database was used to analyze the correlation between c-MYC and DLAT,DLST expression in tumor tissues.The expression level of DLAT and DLST in tumor tissues was evaluated by immunofluorescence staining.Results The high expression of c-MYC gene was negatively correlated with overall survival(P＜0.01).The level of c-MYC protein was positively correlated with the pathological grade of PanIN.Compared with normal tissues,the expression of DLAT and DLST genes in pancreatic cancer cells was increased(P＜0.01).The protein level of c-MYC was positively correlated with those of DLAT and DLST(P＜0.01,P＜0.001).Conclusions The high expression of mitochondrial metabolic enzymes DLAT and DLST in pancreatic ductal adenocarcinoma cells is significantly correlated with the expression level of c-MYC,which increases with the progression of pancreatic cancer.
