Advance of circRNA in the research on orthopedic diseases
10.16352/j.issn.1001-6325.2025.03.0399
- VernacularTitle:CircRNA在骨科疾病中的研究进展
- Author:
Shugang LYU
1
;
Tong ZHAO
;
Guoliang CHEN
;
Xin DU
;
Wenji WANG
Author Information
1. 兰州大学 第一临床医学院,甘肃 兰州 730000
- Keywords:
circular RNA;
orthopedics diseases;
miRNA sponge
- From:
Basic & Clinical Medicine
2025;45(3):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNAs(circRNAs)are a class of closed-loop non-coding RNAs(ncRNAs)formed by head-to-tail covalent bonds.CircRNAs participate in the development of osteoarthritis by regulating extracellular matrix degrada-tion,inflammatory response and homeostasis of chondrocytes;It regulates the osteogenic differentiation of bone mar-row mesenchymal stem cells,the activity of bone microvascular endothelial cells and angiogenesis to affect femoral head necrosis;It regulates the differentiation of bone marrow stem cells,osteoblasts and osteoclasts to cause osteo-porosis and it affects the invasion,metastasis and drug resistance of osteosarcoma through different pathogenesis.CircRNAs are expected to become a new clinical diagnostic marker in the future.
