Effects of intestinal ischemia-reperfusion injury on distal organ function

VernacularTitle:肠缺血/再灌注损伤对远端器官功能的影响
Author: Yurun XING ¹ ; Suying CHEN ; Jinheng TU ; Bosheng HE
Author Information

1. 南通大学第二附属医院影像科,江苏南通 226001
Keywords: ischemia-reperfusion injury; multiple organ dysfunction syndrome; NF-κB signaling pathway; distal organ
From: Basic & Clinical Medicine 2025;45(3):395-398
CountryChina
Language:Chinese
Abstract: Intestinal ischemia-reperfusion(I/R)injury firstly causes damage to the intestine itself.After the intes-tinal barrier and function are impaired,bacteria,metabolites and endotoxins in the intestine will enter the portal system through the damaged intestinal mucosa,and then participate in the systemic microcirculatory system through the liver to act on the distal organs.This leads to further damage and induces reperfusion syndrome and multiple or-gan dysfunction syndromes(MODS),which can lead to death in severe cases.