Role of hyperuricemia in diabetic nephropathy
10.16352/j.issn.1001-6325.2025.03.0378
- VernacularTitle:高尿酸血症在糖尿病肾病中的作用
- Author:
Jie DENG
1
;
Jiali WEI
Author Information
1. 海南医科大学 临床医学系,海南 海口 518110;海南医科大学附属海南医院 肾内科,海南 海口 570311
- Keywords:
hyperuricemia;
uric acid metabolism;
diabetic kidney disease
- From:
Basic & Clinical Medicine
2025;45(3):378-381
- CountryChina
- Language:Chinese
-
Abstract:
Hyperuricemia(HUA),characterized by abnormal uric acid(UA)metabolism,leads to the accumu-lation of urate salts within the kidney.This accumulation not only disrupts glomerular filtration and tubular reab-sorption functions but also triggers oxidative stress,inflammation,and up-regulating the renin-angiotensin-aldoste-rone system(RASS),all of which damage renal cells and tissues.These mechanisms contribute to renal fibrosis and accelerate the progression of diabetic nephropathy(DN)/diabetic kidney disease(DKD).These findings un-derscore the role of HUA as a risk factor for the advancement of DKD,emphasizing the critical importance of ef-fective UA control in delaying its development.
