Relationship between fibrinogen and bone mineral density in patients with spinal degenerative disease
10.16352/j.issn.1001-6325.2025.03.0360
- VernacularTitle:纤维蛋白原与脊柱退行性病变患者骨密度的关系
- Author:
Dongjiang XU
1
;
Wuzheng LIU
;
Kedi WANG
Author Information
1. 首都医科大学附属北京积水潭医院 输血科,北京 100035
- Keywords:
fibrinogen;
osteoporosis;
spinal degenerative disease
- From:
Basic & Clinical Medicine
2025;45(3):360-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between coagulation system biomarkers and bone mineral den-sity(BMD)in patients with spinal degenerative diseases.Methods A total of 251 patients who underwent surgical treatment for spinal degenerative diseases at the Department of Spinal Surgery,Beijing Jishuitan Hospital,from March to October 2019,were enrolled in this study.These patients had both BMD data and coag-ulation system test results available.The distribution of coagulation indicators,including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib),and thrombin time(TT),was analyzed across different gender and BMD groups.Results A retrospective analysis of laboratory coagulation indicators revealed that in male patients,only fibrinogen levels were significantly increased with the reduction of BMD(P＜0.05).PT and APTT did't show significant differences in female patients across BMD groups,but fibrinogen levels increased with the decrease in BMD(P＜0.05).Patients were classified into osteoporosis and non-osteoporosis groups based on their BMD results.Pearson correlation analysis was performed between the binary variable of BMD grouping and patients'coagulation indicators.The results showed a significant negative correlation between BMD grouping and fi-brinogen levels in both genders(P＜0.05).Conclusions Fibrinogen level in patients with spinal degenerative dis-eases significantly increases as BMD decreases,suggesting that fibrinogen may serve as a predictive biomarker for BMD stratification in these patients.
