Nail changes under different CO2 fractional laser parameters using white light interferometry
10.16352/j.issn.1001-6325.2025.03.0354
- VernacularTitle:通过白光干涉仪观察不同参数下CO2点阵激光烧蚀甲面的变化
- Author:
Hongyan MA
1
;
Hongwei WANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 皮肤科,北京 100730
- Keywords:
CO2 fractional laser;
nail channel;
thermal effect;
white light interferometry
- From:
Basic & Clinical Medicine
2025;45(3):354-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of different CO2 fractional laser parameters on the formation of micro-scopic treatment zone(MTZ)on the nail surface and to compare the observations of these areas using various in-struments.Methods This study applied 60 different combinations of CO2 fractional laser parameters,including pulse widths ranging from 100-1 000 μs and powers from 10-60 W,on bovine hoof samples.The formation and overall changes of MTZ on the nail surface were subsequently observed and compared using optical microscopy,in-verted microscopy,and white light interferometry.The relationships between MTZ and various laser parameters were analyzed.Results Significant statistical differences were observed between white light interferometry and inverted microscopy in MTZ assessment(P＜0.001).White light interferometry demonstrated greater accuracy and reliability in measuring micro-ablative column(MAC)and thermal coagulation zone(TCZ).There were also significant statis-tical differences in MAC formation based on CO2 fractional laser parameters(P＜0.001),with the strongest correla-tion found between pulse width and MTZ(0.656 68-0.772 62).Longer pulse widths correlated with larger MAC areas and depths,as well as increased TCZ thickness.Conclusions White light interferometry shows significant advantages in assessing the impact of CO2 fractional laser ablation on tissue depth.These findings provide valuable insights for optimizing laser parameters in the treatment of nail disorders and contribute to enhancing the safety and efficacy of such therapies.
