The role of pleckstrin homology-like domain family A member 1 in metabolic diseases
10.16352/j.issn.1001-6325.2025.02.0268
- VernacularTitle:Pleckstrin同源域家族A成员1在代谢性疾病中的作用
- Author:
Yanmin HU
1
;
Lina PENG
;
Yong YANG
;
Yunxuan XIANG
;
Xiaoyue CHANG
Author Information
1. 内蒙古医科大学 包头临床医学院,包头 014040
- Keywords:
pleckstrin homology-like domain family A member 1(PHLDA1);
endoplasmic reticulum stress;
obese;
cardiovascular diseases
- From:
Basic & Clinical Medicine
2025;45(2):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Pleckstrin homology-like domain family A member 1(PHLDA1)is a pro-apoptotic factor as well as a key regulator of metabolic diseases.In obesity-related diseases,PHLDA1 can reduce liver triglyceride production through inhibition of the expression of sterol regulatory?element binding proteins?1(SREBP?1),and reduce fat syn?thesis through inhibition of peroxisome proliferator?activated receptor γ(PPARγ).However,in cardiovascular dis?eases,PHLDA1 increases vascular calcification,dysfunction,thereby aggravates ischemia?reperfusion injury in the heart and brain.The dual role of PHLDA1 has also been confirmed in tumors.In summary,PHLDA1,as a multi?functional factor,plays different functional roles through various mechanisms.
