Garlic active ingredients in prevention and treatment of osteoarthritis
10.16352/j.issn.1001-6325.2025.02.0249
- VernacularTitle:大蒜的活性成分与骨关节炎的防治
- Author:
Siyu WU
1
;
Xutao SUN
;
Shuo CAO
;
Caiyun MAO
;
Qi ZHOU
;
Yunjia SONG
Author Information
1. 黑龙江中医药大学 基础医学院,黑龙江 哈尔滨 150000
- Keywords:
garlic;
active ingredient;
prevention and treatment;
osteoarthritis
- From:
Basic & Clinical Medicine
2025;45(2):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA)is a common concern over the world.Garlic is a kind of natural herbal medicine,and its active ingredients have shown some anti-inflammatory,antioxidant,anti-catabolic,analgesic and other phar-macological effects.Garlic and its active components alleviate the inflammatory response of OA by inhibiting the ex?pression of inflammatory factors and signal pathways such as NF?κB and PI3K/Akt.They slow down the progression of OA by inhibiting the expression of extracellular matrix(ECM)degrading enzymes.Additionally,they reduce the oxidative damage of joints by upregulating the expression of antioxidant enzymes.Moreover,the active components of garlic can relieve OA pain by activating the potassium ion pathway(Kv7),ATP?sensitive potassium channel(K?ATP),and the nuclear factor erythroid 2?related factor 2(Nrf2)/heme oxygenase 1(HO?1)?NAD(P)H:qui?none oxidoreductase 1(NQO1)signaling pathway.
