Research progress on the interaction between osteoarthritis and cardiovascular diseases
10.16352/j.issn.1001-6325.2025.02.0148
- VernacularTitle:骨关节炎与心血管疾病交互影响的研究进展
- Author:
Jianfeng YANG
1
;
Lin HAO
;
Yan WANG
;
Quanbo JI
Author Information
1. 中国人民解放军总医院 骨科医学部,北京 100853
- Keywords:
osteoarthritis;
cardiovascular disease;
mechanism;
treatment;
prevention
- From:
Basic & Clinical Medicine
2025;45(2):148-153
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA)is closely related to cardiovascular disease(CVD).The incidence of CVD is signifi-cantly higher in the population of OA patients.This review first analyzes the epidemiology and common risk factors of OA and CVD,then discusses the pathogenesis of OA and CVD,and clarifies the roles of chronic low-grade in-flammation,metabolic syndrome,endothelial dysfunction,as well as macrophages,T?cells,and inflammatory fac?tors involved in the mechanisms of interaction between OA and CVD.The review further analyzes treatment strate?gies and preventive measures for OA and CVD,explores the impact of OA treatment drugs on cardiovascular safety,and elucidates the importance of cardiovascular risk assessment and management in OA patients for clinical diagno?sis and treatment.Finally,this review orientes future research directions of OA and CVD,including in?depth explo?ration of the molecular and cellular mechanisms between OA and CVD,drug interactions,and the development of new treatment strategies,aiming to provide ideas for improving the clinical diagnosis,treatment and prognosis of OA and CVD.
