Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection
10.16352/j.issn.1001-6325.2025.01.0130
- VernacularTitle:幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制
- Author:
Hainuo WANG
1
;
Yufan LI
;
Yuying WANG
;
Qianying SHEN
;
Jinxia ZHU
;
Lifei ZHENG
Author Information
1. 首都医科大学 基础医学院,北京 100069
- Keywords:
Helicobacter pylori;
spasmolytic polypeptide-expressing metaplasia
- From:
Basic & Clinical Medicine
2025;45(1):130-134
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori(H.pylori)infection triggers gastric mucosal inflammatory responses and spasmolytic polypeptide-expressing metaplasia(SPEM).These pathological conditions can escalate the severity of chronic gas-tritis,gastric ulcers and even cause gastric cancer.SPEM is frequently viewed as an early sign of gastric mucosal injury and the onset of carcinogenesis.A comprehensive analysis of the genesis and molecular regulation of SPEM cells in the context of H.pylori infection further has enlightened the pathogenesis of gastric mucosal diseases and provide new ideas and targets for diagnosing and treatment of H.pylori-related gastric mucosal diseases.This paper reviews a variety of molecular biomarkers associated with SPEM,encompassing TFF2,CD44v9,and AQP5,and delineates their pivotal regulatory functions in H.pylori infection and SPEM.This paper also reviews the origination of SPEM cells and pertinent molecular regulatory mechanisms.
