Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity
10.16352/j.issn.1001-6325.2025.01.0126
- VernacularTitle:线粒体融合在阿霉素诱导心脏毒性中的作用
- Author:
Yuqi WANG
1
;
Xinyu WANG
;
Haowen LUO
;
Zhaoxin LU
;
Yiwei ZHAO
;
Pan CHANG
Author Information
1. 西安医学院第二临床医学院 麻醉系,陕西 西安 710038
- Keywords:
doxorubicin;
mitochondrial fusion;
cardiotoxicity;
mitofusin(MFN1/2);
nuclear factor-erythroid 2-related factor 2(NRF2)
- From:
Basic & Clinical Medicine
2025;45(1):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Adriamycin is a widely used anti-tumor drug.Targeting mitochondrial fusion proteins/mitofusion 1/2(MFN1/2)and nuclear factor-erythroid 2-related factor 2(NRF2)can up-regulate the expression of mitochondrial fusion protein through PKCε/Stat3/MFN2,SIRT1/MFN2,AMPK/NRF2 and other signaling pathways,promote mitochondrial fusion,maintain kinetic balance and protect mitochondrial function,reduce myocardial cell apoptosis and reduce cardiac toxicity.Understanding the regulatory role and mechanism of mitochondrial fusion in doxorubicin-induced cardio toxicity will provide new strategies for the prevention and treatment of diseases.
