Post-translational modification of Keap1 regulates oxidative stress-related diseases
10.16352/j.issn.1001-6325.2025.01
- VernacularTitle:Keap1翻译后修饰调控氧化应激相关疾病
- Author:
Ying QU
1
;
Caiyun MAO
;
Qing ZHONG
;
Rong ZHANG
;
Yunjia SONG
Author Information
1. 黑龙江中医药大学,黑龙江 哈尔滨 150040
- Keywords:
Keap1;
oxidative stress;
post-translational modifications;
mechanism of action
- From:
Basic & Clinical Medicine
2025;45(1):107-111
- CountryChina
- Language:Chinese
-
Abstract:
The activation of Keap1-Nrf2 signaling pathway is an important mechanism for cells to resist oxidative stress.Under oxidative stress,Keap1 is affected by post-translational modification(PTM)such as glutathione,alky-lation and S-sulfhydrylation,which weakens its binding to Nrf2,leading to Nrf2 accumulation,nuclear translocation and the expression and transcription of downstream detoxification and antioxidant defense proteins.The PTM of Keap1 is involved in the regulation of a variety of oxidative stress-related diseases such as cancer,Parkin-son's disease and atherosclerosis.For example,alkylation inhibits abdominal aortic aneurysm formation,methylation promotes innate resistance of breast cancer,and S-sulfhydrylation improves atherosclerosis,which pro-vides a theoretical basis for finding new drug targets and biomarkers.
