Role of collapsin response mediator proteins in optic nerve injury
10.16352/j.issn.1001-6325.2025.01.0102
- VernacularTitle:脑衰反应调节蛋白在视神经损伤中的作用
- Author:
Yuchun ZHU
1
;
Xinyuan XI
;
Zhen YANG
;
Dongfu FENG
Author Information
1. 上海交通大学附属第六人民医院南院 神经外科,上海 201499
- Keywords:
collapsin response mediator proteins;
optic nerve injury;
retinal ganglion cell;
axonal regeneration
- From:
Basic & Clinical Medicine
2025;45(1):102-106
- CountryChina
- Language:Chinese
-
Abstract:
Collapsin response mediator proteins(CRMPs),also known as dihydropyrimidine-like proteins,contain five isoforms(CRMP1,CRMP2,CRMP3,CRMP4,CRMP5).In central nervous system,CRMPs are mainly in-volved in a variety of physiological processes such as neuronal differentiation and migration,synaptic plasticity,neurite growth and development and guiding extension.Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells(RGCs)after op-tic nerve injury,which may provide new ideas for the treatment of optic nerve injury in the future.
