Research Progress in Imaging Investigation of TERT Promoter Mutations in Gliomas
- VernacularTitle:脑胶质瘤TERT启动子突变的影像学研究进展
- Author:
Yujue ZHONG
1
;
Xiaoxiao MA
;
Qi DUAN
;
Haoxuan LU
;
Jinhao LYU
;
Xin LOU
Author Information
- Keywords: Glioma; Telomerase reverse transcriptase; Magnetic resonance imaging; Positron emission tomography; Review
- From: Journal of Sichuan University (Medical Sciences) 2024;55(6):1350-1356
- CountryChina
- Language:Chinese
- Abstract: Somatic mutations in the promoter region of telomerase reverse transcriptase(TERT),a critical mechanism for telomerase reactivation,play a key role in tumorigenesis.The status of TERT promoter mutation serves as a crucial molecular biomarker for glioma assessment and classification,and is essential for early diagnosis of glioma subtypes,guiding treatment decision-making,and improving patient prognosis.With the recognition of the importance of molecular subtyping of gliomas,there has been a surge in research on non-invasive prediction of key molecular biomarkers based on preoperative imaging of gliomas,with a particular focus on TERT promoter studies using radiomics approaches.This article presents a comprehensive review of research on TERT promoter mutations in gliomas and imaging-related studies,with the goal of providing insights for future studies on non-invasive prediction of TERT promoters status and offering important references for the precision diagnosis and treatment of glioma patients.
