Efficacy of Combining Highly Aspherical Lenslets Spectacles With 0.01％Atropine Eye Drops in Myopia Control
- VernacularTitle:高非球微透镜框架眼镜联合0.01％阿托品滴眼液的近视控制效果分析
- Author:
Yuxuan ZHAO
1
;
Bi YANG
;
Xiaoying LI
;
Wei MA
;
Longqian LIU
;
Naihong YAN
Author Information
- Keywords: Myopia; Atropine; Eyeglasses
- From: Journal of Sichuan University (Medical Sciences) 2024;55(5):1280-1287
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the difference in myopia control efficacy between spectacle lenses with highly aspherical lenslets(HAL)combined with 0.01％atropine eye drops and spectacle lenses with HAL alone or single vision spectacle lenses(SVL)in children and adolescents.Methods A retrospective cohort study was conducted with a total of 105 myopic children aged 6-15 years.According to the specific myopia correction and control methods of each subject,they were evenly divided into the HAL+0.01％atropine(HAL+AT)group,the HAL group,and the SVL group,with 35 subjects in each group.Relevant data,such as cycloplegic refraction and axial length(AL)at baseline and 12 months after wearing spectacles,were retrieved.One-way analysis of variance,or the Kruskal-Wallis test,was used to analyze the changes in AL and spherical equivalent refraction(SER)after wearing spectacles for 12 months in comparison to those at baseline in the three groups.Results There was no statistically significant difference in the baseline parameters and duration of wearing spectacles among the three groups(P＞0.05).After wearing spectacles for 12 months,the changes in SER were-0.13(-0.25,0.00)D,-0.25(-0.63,-0.25)D,and-0.63(-1.00,-0.25)D in the HAL+AT group,HAL group,and SVL group,respectively;AL elongation in the three groups was(0.09±0.11)mm,(0.19±0.16)mm,and(0.34±0.16)mm,respectively.The HAL+AT group exhibited slower SER changes(PHAL+AT vs.HAL=0.00 1,PHAL+AT vs.SVL=0.002)and AL elongation(PHAL+AT vs.HAL=0.009,PHAL+AT vs.SVL=0.001)than those of the HAL and the SVL groups.Compared with those of the SVL group,myopia progression was reduced by 79.4％and AL elongation was slowed down by 73.5％in the HAL+AT group,while in the HAL group,myopia progression and AL elongation were reduced by 60.3％and 44.1％,respectively.According to stratified analysis based on age and myopia progression rate,among younger children aged 6 to 8 years and older children aged 9 to 15 years,the HAL+AT group had a significantly lower proportion of subjects experiencing fast AL elongation(AL＞0.36 mm/year)and a significantly higher proportion of subjects experiencing slow AL elongation(AL≤0.18 mm/year)compared to the SVL group(P＜0.017).Conclusion The combination intervention of spectacle lenses with HAL and 0.01％atropine eye drops is effective in controlling myopia progression in children and adolescents,with better myopia control effect achieved using this combination intervention in myopic children of all ages.
