Clinical Research Progress on Using κ-Opioid Receptor Agonists to Treat Uremic Pruritus
- VernacularTitle:κ阿片受体激动剂治疗尿毒症瘙痒临床研究进展
- Author:
Mei YANG
1
;
Yupei LI
;
Qinbo YANG
;
Baihai SU
Author Information
- Keywords: Uremic pruritus; κ-opioid receptor agonists; Nalfurafine; Nalbuphine
- From: Journal of Sichuan University (Medical Sciences) 2024;55(4):1044-1048
- CountryChina
- Language:Chinese
- Abstract: Uremic pruritus,a severe complication in patients with chronic kidney disease,is associated with a high prevalence.It can cause depression and sleep disorders,and seriously affect the quality of life and the social relations of patients.Recently,there is growing evidence showing that κ-opioid receptor agonists,including nalfurafine,difelikefalin,and nalbuphine,can effectively and safely reduce itching symptoms in patients with refractory uremic pruritus.Herein,we reviewed the epidemiology,pathogenesis,clinical symptoms,and treatment strategies of uremic pruritus,and summarized in detail the progress in clinical research on the use of κ-opioid receptor agonists,including nalfurafine,difelikefalin,and nalbuphine,in the management of patients with uremic pruritus.
