Research Progress in Stress-Induced Senescence of Renal Tubular Cells in Diabetic Nephropathy
- VernacularTitle:肾小管上皮细胞应激性衰老在糖尿病肾病中的研究进展
- Author:
Xiangling YI
1
;
Yani HE
;
Kehong CHEN
Author Information
- Keywords: Renal tubular epithelial cells; Stress-induced senescence; Diabetic nephrology; Review
- From: Journal of Sichuan University (Medical Sciences) 2023;54(6):1085-1090
- CountryChina
- Language:Chinese
- Abstract: Diabetic nephropathy(DN)is the leading cause of end-stage renal disease.Renal tubulointerstitial injury is an important pathophysiological basis that contributes to the progression of DN to end-stage renal disease.Stress-induced senescence of renal tubular epithelial cells(RTECs)forms a key link that causes tubulointerstitial injury.In recent years,it has been reported that organelles,such as endoplasmic reticulum,mitochondria,and lysosomes,in RTECs are damaged to varying degrees in DN,and that their functional imbalance may lead to stress-induced senescence of RTECs,thereby causing sustained cellular and tissue-organ damage,which in turn promotes the progression of the disease.However,the core mechanism underlying changes in the senescence microenvironment caused by stress-induced senescence of RTECs in DN is still not understood.In addition,the mechanism by which organelles lose homeostasis also needs to be further investigated.Herein,we described the specific pathophysiological mechanisms of renal tubular injury,stress-induced senescence of RTECs,and their association with organelles in the context of DN in order to provide reference for the next-step research,as well as the development of new therapeutic strategies.
