The Expression of Interleukin-17 in Blood and Nasal Tissue of Patients with Allergic Rhinitis and Nasal Polyps
10.3969/j.issn.1672-173X.2010.02.011
- VernacularTitle:白介素-17在变应性鼻炎及鼻息肉患者血液和组织中的表达
- Author:
Jin-Tao DU
1
;
Luo BA
;
Ting-Ting SHANG
;
Ya-Feng LIU
;
Da-Peng WEI
;
Hui-Min AN
Author Information
1. 四川大学华西医院
- Keywords:
Interleukin-17;
Allergic rhinitis;
Nasal polyps;
Eosinophils
- From:
Journal of Sichuan University (Medical Sciences)
2010;41(2):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of IL-17 in blood and nasal tissue of allergic rhinitis and nasal polyps, and to investigate the possible mechanism of IL-17 in the progress of allergic rhinitis and nasal polyps. Methods There were 41 patients enrolled, including the patients with allergic rhinitis, nasal polyps and deviated nasal septum. The blood and nasal mucosa tissue or nasal polyps were collected in all the patients. The expression of IL-17 was measured by the methods of ELISA and immunohistochemisty, and the number of eosinophils and IL-17 positive cells was measured. Results The IL-17 expression of nasal polyps was significantly elevated in the blood and nasal tissue, which was obviously correlated with the number of eosinophils infiltrated in nasal tissue. However, for the patients with allergic rhinitis, there was only apparent expression of IL-17 in nasal mucosa. Conclusion IL-17 plays an important role in the development of nasal polyps, but for allergic rhinitis, it needs further study as an potential important aspect of the pathogenesis.
