The Expression and Clinical Significance of Wnt-1 Induced Secreted Protein-1 in Breast Carcinoma
10.3969/j.issn.1672-173X.2010.02.010
- VernacularTitle:Wnt-1诱导分泌蛋白-1在乳腺浸润性导管癌中的表达及其临床意义
- Author:
Rui HU
1
;
Chao TIAN
;
Wen-Jian MENG
;
Jian-Hui ZHANG
;
Lui LI
;
Pu-Rong ZHANG
;
Qi-Ming LONG
;
Ping TAO
Author Information
1. 四川省肿瘤医院
- Keywords:
Breast carcinoma;
Wnt-1 induced secreted protein-1
- From:
Journal of Sichuan University (Medical Sciences)
2010;41(2):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Wnt-1 induced secreted protein-1(WISP-1) between breast cancer and paired normal breast tissues and to explore the significance of WISP-1 in breast cancer tumorigenesis. Methods The mRNA and protein expressions of WISP-1 in human breast cancer were measured by Quantitative Real-Time RT-PCR and immunohistochemical staining and further analyzed the relationship between WISP-1 expression and clinic pathologic characters. Results WISP-1 expression in breast cancer was higher than that in normal breast tissue (P=0.001). The mRNA expression level of WISP-1 was correlated with tumor size, staging, lymph node status, differentiated degree and HER-2 status (P<0.05). WISP-1 protein expression level was correlated with lymph node status, differentiated degree and HER-2 status (P<0.05). Conclusion WISP-1 expression in human breast cancer increases significantly and may play a key role in the invasion and metastasis of human breast cancer.
