The Photostability of Hydrocortisone Injection
10.3969/j.issn.1672-173X.2001.02.048
- VernacularTitle:氢化可的松注射液在光作用下的稳定性研究
- Author:
Tao LIN
1
;
Kailan LI
;
Chengrong LI
;
Chang QIU
;
Xiancheng ZHAN
Author Information
1. School of Pharmacy, WCUMS
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):315-316,324
- CountryChina
- Language:Chinese
-
Abstract:
Objective This experiment was designed to make known wether the photostability of drugs in daylight can be obtained from lamplight exposure. Methods A self made cumulative illuminometer via pulse counting method was used for measuring cumulative illuminance of daylight to investige the photodegradation of Hydrocortisone injection in various lamp light and daylight; the equivalent influences of different light sources on the photostability of the injection were obtained，and the shelf-life in indoor daylight of the drug was predicted. Results The photodegradation of Hydrocortisone injection obeys zero order kinetics: C=C0-kEt; the shelf-life in indoor daylight of the injection in nude ampoules was predicted as 36 days and is comparable to 35 days in a long-term storage test. Conclusion The photostability of drugs in daylight can be obtained from lamplight exposure experiment.
