Polycystic Ovaraian Syndrome and Hyperinsulinemia
10.3969/j.issn.1672-173X.2001.02.044
- VernacularTitle:多囊卵巢综合征与高胰岛素血症的关系
- Author:
Liangzhi XU
1
;
Limin YUE
;
Shiqiao TAN
;
Shizhi YANG
;
Dongsheng QIU
;
Yaling KONG
;
Daiwen HAN
;
Rong HU
;
Li DENG
;
Liang LI
;
Jinhu ZHANG
Author Information
1. The Second Affiliated Hospital WCUMS
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the relationship between polycystic ovarian syndrome and hyperinsulinemia. Methods Age, body height, body weight, serum estradiol, progesterone, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin(PRL), triiodothyronine (T3), tetraiodothyronine (T4), insulin, oral glucose tolerance test (OGTT), and cortisol were measured in 28 patients with polycystic ovarian syndrome (PCOS).Results Sxiteen patients (57.1% of total) had hyperinsulinemia. Among them one patient was found diabetic. No difference was noted in age, height, body weight, body mass index, serum estradiol, progesterone, testosterone, FSH, LH, PRL, T3, T4, cortisol, and glucose of OGTT between hyperinsulinemia and non-hyperinsulinemia patients. However the LH/FSH ratio(2.4±1.5) in hyperinsulinemia patients was significantly higher than 1.2±0.6 in non-hyperinsulinemia patients （P=0.0125）. In addition, the results showed that the fasting serum insulin, insulin after OGTT,the insulin/glucose ratio at 30, 120 minutes, 180 minutes, the area under curve of and the insulin, insulin resistant index (IRI) were higher in hyperinsulinemia pateints than in non-hyperinsulinemia patients respectively. Furthermore, the fasting insulin level, insulin/glucose ratio were found to be negatively related to insulin sensitivity index and positively related with β-cell functioning index. Conclusion Hyperinsulinemia and insulin resistance accompany with some of the PCOS patients in China. Further investigations will be necessary to clarify the relevant mechanisms.
