The Risk of Sustained Amenorrhea in Patients with Systemic Lupus Erythematosus Receiving Intermittent Pulse Cyclophosphamide Therapy
10.3969/j.issn.1672-173X.2001.02.041
- VernacularTitle:大剂量环磷酰胺冲击治疗系统性红斑狼疮时的闭经危险
- Author:
Gang LIU
1
;
Yongtao CHEN
;
Ling WANG
;
Chuan ZUO
;
Qibing XIE
;
Zhongming WANG
;
Maoxian LIN
Author Information
1. the First Affiliated Hospital
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):294-295,306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the risk of sustained amenorrhea in premenopausal women with systemic lupus erythematosus (SLE) receiving intermittent pulse cyclophosphamide (CTX) therapy. Methods Prospectively comparing the amenorrhea rate of 51 cases receiving intermittent pulse cyclophosphamide therapy versus that of 22 cases receiving intermittent pulse methylprednisolone (MP) therapy. Results The amenorrhea rate was higher in the CTX group (19.6%) than in the MP group (P=0.025).In the CTX group, the amenorrhea rate of patients aged over 30 was higher than that of patients aged 30 or below 30 (P=0.0018). Conclusion Pulse CTX therapy in fertile women with SLE is associated with increased rate of sustained amenorrhea, and the older the patient is, the higher risk for sustained amenorrhea the patient runs.
