The Change of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Neurons of Cerebral Cortex of Adult Rat Following Local Ischemia
10.3969/j.issn.1672-173X.2001.02.017
- VernacularTitle:脑缺血后大脑皮质神经生长因子和脑源性神经营养因子的改变
- Author:
Jing ZENG
1
;
Tinghua WANG
;
Xiao ZHANG
;
Lanlan MI
;
Li GAO
Author Information
1. Kunming Medical College
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):216-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective To acquire knowledge about the change of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in neurons of cerebral cortex of adult rat following local ischemia. Methods Using specific antiserums of NGF and BDNF by immunohistochemical ABC method. Results NGF-like and BDNF-like immunoreactions distributed mainly in the neurons of the third and fifth layers in cerebral cortex. After local ischemia, the average gray degrees of NGF and BDNF in neurons of cerebral cortex both decreased on the operated side more than on the un-operated side. Conclusion This experiment demonstrated that the levels of NGF and BDNF in neurons of cerebral cortex following ischemia were upregulated apparently, suggesting that NGF and BDNF may play an important role in the process of neurons' reaction after ischemia.
