TGFβ1 and ET-1 Expression in the Peripheral Blood of Patients with Cirrhosis
10.3969/j.issn.1672-173X.2001.02.013
- VernacularTitle:肝硬化患者外周血中TGFβ1和ET-1的表达
- Author:
Li YANG
1
;
Xiaojing LIU
;
Hua FU
;
Ou QIANG
;
Minghui HUANG
Author Information
1. the First Affiliated Hospital
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):202-203,212
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aims of this study were to determine ① the variation of blood TGFβ1 and ET-1 in patients with liver cirrhosis; ② the relationship of the blood TGFβ1 and ET-1 with Child degree of liver function and the severity of esophageal varices. Methods Peripheral blood samples were obtained from 72 patients and 24 normal controls.The blood levels of TGFβ1 and ET-1 were measured by using a standard bioassay and the radioimmunoassay.Results TGFβ1 level （11.77±1.32 ng/ml）and ET-1 level（78.37±17.54 pg/ml） were significantly higher in the patients than those in controls(P<0.05). The increase of the ET-1 in the patients is closely associated with Child degree of liver function (r=0.94) and the severity of esophageal varices(r=0.87). TGFβ1 concentration is not associated with Child degree of liver function (r=0.11) and the severity of esophageal varices (r=0.03) . Conclusion TGFβ1 and ET-1 may play an important role in the pathophysiologic process of cirrhosis. ET-1 concentration may reflect portal hypertension development.
