The Protein Expression of p53 and bcl-2 in Laryngeal Squamous Cell Carcinoma
10.3969/j.issn.1672-173X.2001.02.009
- VernacularTitle:p53、bcl-2基因在喉鳞癌中的蛋白表达及其临床意义
- Author:
Shixi LIU
1
;
Siquan TANG
;
Yinghe LIN
;
Chuanyu LIANG
Author Information
1. the First Affiliated Hospital WCUMS
- From:
Journal of Sichuan University (Medical Sciences)
2001;32(2):191-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the relationship of p53 and bcl-2 gene to laryngeal carcinoma. Methods p53 and bcl-2 protein expressions were examined in the specimens of 60 laryngeal carcinomas and 8 vocal cord polyps by immunohistochemistry method. Results Overexpressions of p53 and bcl-2 were found in the laryngeal carcinoma specimens; the positive rates of p53 and bcl-2 protein expression were 61.7%(37/60) and 43.3%(26/60), respectively. Nagative results were observed in all the vocal cord polyp specimens. The positive rates of p53 and bcl-2 expression were related to the histological grade and cervical lymphatic metastasis of laryngeal carcinoma but not related to clinical stage and tumor types. Conclusion The results of this study support the hypothesis that p53 and bcl-2 gene may be involved in the apoptosis of laryngeal carcinoma and they may play an important role in the pathogenesis of laryngeal cancer.
