Study on neuroplasticity of local functional activity of the brain during gravity re-adaptation after 90 days-6 degree head-down bed rest
10.16289/j.cnki.1002-0837.2024.05004
- VernacularTitle:90天-6°卧床后重力再适应过程中大脑局部功能活动重塑研究
- Author:
Yawen LIU
1
;
Pengling REN
;
Kai LI
;
Linkun CAI
;
Tingting ZHANG
;
Ke LYU
;
Penggang QIAO
;
Han LYU
;
Dehong LUO
;
Lina QU
;
Yinghui LI
;
Zhenchang WANG
Author Information
1. 首都医科大学附属北京友谊医院放射科,北京 100050;北京市临床医学研究所精准与智慧影像实验室,北京 100050
- Keywords:
simulated weightlessness;
head-down bed rest;
gravity re-adaptation;
local brain functional activity;
neuroplasticity
- From:Space Medicine & Medical Engineering
2024;35(5):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and compare the changes in local functional activity of the brain under different recovery times after a 90-day,-6° head down bed rest(HDBR)experiment,clarify the mechanism of brain function remodeling during gravity adaptation,and provide imaging basis and guidance for the model construction and health assessment.Methods 36 healthy male volunteers underwent resting-state functional magnetic resonance imaging(rs-fMRI)scans before HDBR(PRE),3 days after 90-day HDBR(R+3),and 26-28 days after 90-day HDBR(R+26-28),and calculated regional homogeneity(ReHo)and low-frequency amplitude(ALFF)and perform statistical analysis between different time points.Results Compared with PRE-status,ReHo value in the left inferior parietal gyrus and ALFF value in the right posterior cingulate gyrus decreased significantly in R+3 status,while ReHo value in the left calcarine,right lingual gyrus and ALFF value in the precuneus,left paracentral lobule,and right postcentral gyrus increased significantly.At R+26-28 status,more brain areas showed significant changes.Conclusion 90 days of long-term HDBR and subsequent recovery will lead to changes in the neural functional activities of the brain's default network,sensorimotor network and visual network,and obvious adaptive remodeling will occur after a longer period of gravity re-adaptation and recovery.
