Prognostic value of serum PCT,SAA,and HBP in pediatric patients with sepsis
10.3969/j.issn.1009-0754.2025.11.013
- VernacularTitle:血清PCT、SAA和HBP在脓毒血症患儿预后评估中的价值
- Author:
Yuchun GAO
1
;
Ling CAO
;
Yong XUE
;
Li ZHOU
Author Information
1. 224700 江苏盐城,南通大学杏林学院附属建湖医院儿科
- Keywords:
Sepsis;
Procalcitonin;
Heparin-binding protein;
Serum amyloid A;
Children;
Prognostic value
- From:
Journal of Navy Medicine
2025;46(11):1139-1144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of serum procalcitonin(PCT),serum amyloid A(SAA),and heparin-binding protein(HBP)in pediatric patients with sepsis.Methods A total of 92 pediatric patients diagnosed with sepsis and admitted to Jianhu Hospital Affiliated to Xinglin College of Nantong University from May 2020 to May 2023 were retrospectively analyzed.Based on 28-day outcomes,the patients were categorized into survival group(n=65)and death group(n=27).Serum levels of PCT,SAA,and HBP were compared between the two groups.Their correlations with the Acute Physiology and Chronic Health Evaluation II(APACHE II)score were assessed using Spearman analysis.Multivariate logistic regression was performed to identify independent risk factors for poor prognosis.The predictive performance of PCT,SAA,and HBP for adverse outcomes was evaluated using receiver operating characteristic(ROC)curve.Results There were significant differences in terms of hospital stay,APACHE II score,SOFA score,and serum levels of PCT,SAA,and HBP between the two groups(P<0.05).Spearman correlation analysis indicated positive correlations between APACHE II score and serum levels of PCT,SAA,and HBP(P<0.05).Multivariate regression analysis revealed that elevated APACHE II and SOFA scores,as well as high levels of PCT,SAA,and HBP were independent risk factors for poor prognosis(P<0.05).Combined detection of PCT,SAA,and HBP showed high prognostic value,with an area under the ROC curve(AUC)of 0.868,sensitivity of 90.0%,and specificity of 96.8%.Conclusion Abnormal expression in serum PCT,SAA,and HBP are closely associated with poor prognosis in pediatric patients with sepsis.These biomarkers may serve as valuable indicators for predicting clinical outcomes of sepsis.
