Efficacy of low-frequency versus high-frequency repetitive transcranial magnetic stimulation in the treatment of tremor-dominant Parkinson's disease
10.3969/j.issn.1009-0754.2025.11.007
- VernacularTitle:低频与高频重复经颅磁刺激治疗震颤型帕金森病的疗效观察
- Author:
Jing CHEN
1
;
Lulu XIAO
;
Juan DU
;
Xiang ZHANG
Author Information
1. 223800 江苏宿迁,徐州医科大学附属宿迁医院/南京鼓楼医院集团宿迁医院神经内科
- Keywords:
Tremor-dominant Parkinson's disease;
Low-frequency repetitive transcranial magnetic stimulation;
High-frequency repetitive transcranial magnetic stimulation;
Cortical excitability
- From:
Journal of Navy Medicine
2025;46(11):1103-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of low-frequency and high-frequency repetitive transcranial magnetic stimulation(rTMS)in patients with tremor-dominant Parkinson's disease.Methods A total of 88 tremor-dominant Parkinson's disease patients who visited Suqian Hospital of Nanjing Drum Tower Hospital Group from January 2021 to June 2024 were randomly assigned to low-frequency rTMS group(treated by 1 Hz stimulation)and high-frequency rTMS group(treated by 5 Hz stimulation),with 44 patients in each group.Treatment was administered once a day,five times a week,for 4 weeks.Another 50 patients were enrolled as the control group.During the rTMS treatment,regular medications were continuously administrated.Before and after treatment,the following assessments were conducted:unified parkinson's disease rating scale part Ⅲ(UPDRS-Ⅲ),Parkinson's disease questionnaire-39(PDQ-39),timed up and go(TUG)test,tremor amplitude,tremor peak frequency,and cortical excitability(resting motion threshold[rMT]and active motion threshold[aMT]).Results After treatment,there were significant differences in the UPDRS-Ⅲ score,TUG time,PDQ-39 score,rMT and aMT values,and tremor amplitude between the two groups(P<0.05),and the high-frequency rTMS group was lower/shorter than the other two group.There was no significant difference in tremor peak frequency between the two groups(P>0.05).Conclusion Both low-frequency and high-frequency rTMS can significantly improve motor function and quality of life in tremor-dominant Parkinson's disease patients.High-frequency rTMS demonstrates better efficacy in improving various symptoms and provides a more effective treatment option for tremor-dominant Parkinson's disease.
