Clinical outcomes of salbutamol sulfate combined with reduced glutathione in the treatment of acute exacerbation of chronic obstructive pulmonary disease in elderly patients
10.3969/j.issn.1009-0754.2025.10.009
- VernacularTitle:硫酸沙丁胺醇联合还原型谷胱甘肽治疗老年慢性阻塞性肺疾病急性加重期的临床研究
- Author:
Xiaowei WANG
1
;
Yanlan XU
Author Information
1. 201700 上海,复旦大学附属中山医院青浦分院老年科
- Keywords:
Chronic obstructive pulmonary disease;
Salbutamol sulfate;
Reduced glutathione;
Acute exacerbation
- From:
Journal of Navy Medicine
2025;46(10):1020-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of salbutamol sulfate combined with reduced glutathione in treating acute exacerbation of chronic obstructive pulmonary disease(COPD)in the elderly.Methods A total of 103 elderly patients with acute exacerbation of COPD who were admitted to the Qingpu Branch of Zhongshan Hospital,Fudan University from January 2020 to June 2022 were randomly assigned to three groups.Control group 1(34 cases)received nebulized normal saline treatment.Control group 2(34 cases)received conventional treatment(e.g.,oxygen therapy,anti-infection,expectorant therapy,etc.)plus reduced glutathione.Treatment group(35 cases)received additional salbutamol sulfate on the basis of the control group 2.The treatment course was 12 days.Lung function,inflammatory factors,COPD assessment test,(CAT)score,BODE index,cardiopulmonary oxygenation function,6-minute walk test(6MWT)distance,modified medical research council dyspnea scale(mMRC)score,St.George's respiratory questionnaire(SGRQ)score,acute exacerbation frequency within 2 years,and adverse reactions were recorded.Results After treatment,the forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and FEV1/FVC ratio in the treatment group were significantly higher than those in the control groups,while procalcitonin(PCT)and C-reactive protein(CRP)levels in the treatment group were significantly lower than those in the control groups(P<0.05).The treatment group exhibited lower CAT scores and BODE indices,higher maximal oxygen uptake(VO2max),metabolic equivalent of task at peak exercise(METspk),and respiratory frequency at peak exercise(RFEspk),longer 6MWT distances,and lower mMRC and SGRQ scores as compared with the control groups(P<0.05).The frequency of acute exacerbation in the treatment group was lower than that in the control groups at 6 months,1 year,and 2 years after treatment(P<0.05).No significant differences in adverse reactions were observed among the three groups(P>0.05).Conclusion The combination of salbutamol sulfate and reduced glutathione can significantly improve lung function,reduce inflammation,enhance quality of life,decrease acute exacerbation frequency,and demonstrate good safety in elderly patients with acute exacerbation of COPD.
