Predictive role of ferroptosis-related gene markers in gastric cancer prognosis
10.3969/j.issn.1009-0754.2025.10.008
- VernacularTitle:铁死亡基因标志物对胃癌预后的预测作用
- Author:
Zhao HAO
1
;
Min LI
Author Information
1. 572000 海南 三亚,南部战区海军第二医院
- Keywords:
Gastric cancer;
Ferroptosis;
Prognosis;
Immune infiltration
- From:
Journal of Navy Medicine
2025;46(10):1012-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct a prognostic model based on a ferroptosis-related protein prognostic index(PI)and clinical variables,and then validate its efficacy.Methods Gastric adenocarcinoma data from The Cancer Genome Atlas(TCGA)database were downloaded as training cohort,and the GSE62254 dataset from the Gene Expression Omnibus(GEO)database were served as validation cohort.Differentially expressed genes between tumor and normal tissues were intersected with ferroptosis-related genes.R software was utilized for data analysis,visualization,and model construction of the training chort,followed by validation in the validation cohort.Enrichment analysis and immune cell infiltration analysis were performed on the identified key genes.Results The expression levels of ACSF2,CYP4F8,EZH2,and SOCS2 were identified as independent risk factors for gastric cancer(all P<0.05).The predictive model based on the expression levels of the four ferroptosis-related genes and clinical variables demonstrated strong predictive ability for 1-,3-,and 5-year survival in patients with gastric cancer.Functional analysis revealed significant associations of these genes with biological processes such as negative regulation of multicellular organisms,constitutive heterochromatin assembly,chromatin silencing complex,insulin-like growth factor receptor binding,long-chain fatty acid ligase activity,growth hormone receptor binding,lysine degradation,and arachidonic acid metabolism.Conclusion A novel nomogram based on ferroptosis-related genes and clinical factors is established to predict prognosis in gastric cancer patients.
