Effect of Jiawei Ditan Decoction on neurological function,PTX-3 and VEGF in patients with post-ischemic stroke cognitive impairment
10.3969/j.issn.1009-0754.2025.09.012
- VernacularTitle:加味涤痰汤对缺血性脑卒中后认知功能障碍患者神经功能及五聚素-3、血管内皮生长因子的影响
- Author:
Yuyu LIU
1
;
Rumeng ZHANG
;
He ZHU
;
Lailai WEI
;
Linfei LI
;
Qian HU
;
Xiujuan WANG
Author Information
1. 221000 江苏徐州,徐州市中心医院药剂科
- Keywords:
Jiawei Ditan Decoction;
Ischemic stroke;
Cognitive impairment;
Neurological function
- From:
Journal of Navy Medicine
2025;46(9):923-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Jiawei Ditan Decoction on neurological function,pentraxin-3(PTX-3),and vascular endothelial growth factor(VEGF)in patients with post-ischemic stroke cognitive impairment(PSCI).Methods A total of 97 patients with PSCI who were admitted to Xuzhou Central Hospital from March 2022 to March 2024 were enrolled and randomly assigned to control group(n=48)or decoction group(n=49)using the envelope drawing method.The control group received conventional treatment,while the decoction group was additionally treated with Jiawei Ditan Decoction.Clinical efficacy,Traditional Chinese Medicine(TCM)syndrome scores,cognitive and functional assessments,laboratory markers,and oxidative stress levels were compared between the two groups.Results The total effective rate in the decoction group was significantly higher than that in the control group(P<0.05).At 3 and 6 months after treatment,TCM syndrome scores in the decoction group were lower than those in the control group(P<0.05).The scores of the Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE),and Barthel index(BI)in the decoction group were higher than those in the control group at 3 months after treatment,while the National Institutes of Health stroke scale(NIHSS)score in the decoction group was lower than that in the control group(P<0.05).At 1 month after treatment,PTX-3 and hypersensitive C-reactive protein(hs-CRP)levels in the decoction group were lower than those in the control group,while VEGF,superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and nitric oxide(NO)levels in the decoction group were higher than those in the control group(P<0.05).Conclusion Jiawei Ditan Decoction exhibits significant effects on improving neurological function and modulating PTX-3 and VEGF levels in patients with PSCI.
