Effects of vitamin D combined with leuprorelin on hormone levels and development in girls with idiopathic central precocious puberty
10.3969/j.issn.1009-0754.2025.09.011
- VernacularTitle:维生素D联合亮丙瑞林对特发性中枢性性早熟女童性激素水平和发育情况的影响
- Author:
Tao YIN
1
;
Jiayun LU
;
Shu SUN
;
Wei HU
;
Mingmei SONG
Author Information
1. 214000 江苏无锡,联勤保障部队第九〇四医院
- Keywords:
Idiopathic central precocious puberty;
Vitamin D;
Leuprorelin;
Sex hormones
- From:
Journal of Navy Medicine
2025;46(9):918-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of vitamin D combined with leuprorelin in girls with idiopathic central precocious puberty(ICPP).Methods A total of 102 girls with ICPP treated at The Fifth People's Hospital of Wuxi from January 2021 to January 2024 were selected and assigned to control group or observation group according to different treatment methods,with 51 girls in each group.The control group received subcutaneous injections of leuprorelin,while the observation group received vitamin D supplementation in addition to the leuprorelin injections.Both groups were treated for 12 months.The total effective rate,sex hormone levels(estradiol[E2],follicle-stimulating hormone[FSH],luteinizing hormone[LH]),primary sex characteristics(ovarian volume and uterine volume),growth metrics(height,body mass index[BMI],bone age,predicted adult height[PAH]),adverse reactions were compared between the two groups.Results The observation group had higher total effective rate than the control group.After treatment,sex hormone levels,ovarian volume,uterine volume,BMI,and bone age in the observation group were significantly lower than those in the control group,while height and PAH in the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Vitamin D combined with leuprorelin can contribute to lowering sex hormone levels,slowing skeletal maturation,and improving PAH in ICPP girls.
