Risk factors of hyperhomocysteinemia in military pilots
10.3969/j.issn.1009-0754.2025.06.002
- VernacularTitle:军事飞行人员高同型半胱氨酸血症危险因素分析
- Author:
Junwei YANG
1
;
Xiufang WU
;
Chunhong PAN
;
Haimei TANG
;
Tao ZHAO
Author Information
1. 541002 广西 桂林,联勤保障部队桂林康复疗养中心
- Keywords:
Military pilots;
Hyperhomocysteinemia;
Risk factors;
Health management
- From:
Journal of Navy Medicine
2025;46(6):547-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiological characteristics and risk factors of hyperhomocysteinemia(HHcy)in military aircrew.Methods A retrospective study was conducted on 506 aircrew convalescents undergoing health examination from September 2023 to April 2024.Demographic,lifestyle,and biochemical data were analyzed.The risk factors of HHcy were identified by x2 test and multivariate Logistic regression.Results The HHcy detection rate was 21.94%(111/506),with a median homocysteine(Hcy)level of 11.75(9.70-14.30)μmol/L.Multivariate analysis revealed that smoking(OR=2.093,95%CI:1.313-3.336),service in conventional fighter aircraft(OR=1.716,95%CI:1.063-2.770),elevated low-density lipoprotein cholesterol(LDL-C)(OR=2.510,95%CI:1.413-4.458),and elevated bilirubin(OR=2.360,95%CI:1.509-3.691)were independent risk factors for HHcy(all P<0.05).Conclusion There is a high prevalence of HHcy in military pilots.It is strongly associated with smoking,aircraft type,and metabolic abnormalities.It is recommended to incorporate Hcy testing into routine physical examination,implement risk factor-based stratified interventions,and establish an atherosclerotic cardiovascular diseases early warning system integrating vascular imaging and risk assessment,aiming to reduce cardiovascular risks and safeguard combat effectiveness.
