Short-term outcomes of pocket endoscopic submucosal dissection and endoscopic mucosal resection in treatment of early colorectal cancer
10.3969/j.issn.1009-0754.2025.04.014
- VernacularTitle:口袋法内镜黏膜下剥离术与内镜下黏膜切除术治疗早期结直肠癌的短期疗效对比
- Author:
Xinyao WU
1
;
Zhili ZHAO
;
Dandan JIANG
;
Xiaoqi LONG
;
Bin YANG
Author Information
1. 629000 四川 遂宁,遂宁市中心医院
- Keywords:
Pocket method;
Endoscopic submucosal dissection;
Endoscopic mucosal resection;
Colorectal cancer
- From:
Journal of Navy Medicine
2025;46(4):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the short-term outcomes and postoperative complications of endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)in the treatment of early colorectal cancer.Methods A total of 110 patients with early colorectal cancer who were admitted to Suining Central Hospital from June 2020 to June 2022 were prospectively enrolled and randomly assigned to two groups by random number table.Of them,58 patients underwent ESD and 52 patients underwent EMR.Operation related indexes,inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α],and C-reactive protein[CRP])before operation and 3 days after operation,and postoperative quality of life index(QL-Index)were compared between the two groups.The complications of the two groups were observed.Results The operation time,hospital stay,postoperative exhaust time,defecation time,and intraoperative blood loss in ESD group were lower than those in EMR group,and the rates of complete resection and en bloc resection in ESD group were higher than those in EMR group(P<0.05).The levels of IL-6,TNF-α and CRP were increased 3 d after operation in both groups,but the levels of IL-6,TNF-α and CRP in ESD group were lower than those in EMR group(P<0.05).The total score of QL-Index and the scores of activity,daily activities,health,and overall situation in ESD group were significantly higher than those in EMR group(P<0.05).The incidence of complications in ESD group was higher than that in EMR group,without significant difference(P>0.05).Conclusion The pocket ESD can effectively promote postoperative rehabilitation,increase resection rate,reduce postoperative inflammation,and improve the quality of life of patients with early colorectal cancer,and there is no obvious complication.
