Hemorrhagic transformation and its high-risk factors in patients with acute cerebral infarction treated with alteplase
10.3969/j.issn.1009-0754.2025.03.011
- VernacularTitle:急性脑梗死患者接受阿替普酶治疗后发生出血转化现状调查及其高危因素探究
- Author:
Qing YANG
1
;
Chunxia GE
;
Aiping CAO
;
Xiaowei XU
;
Yu NIU
Author Information
1. 226600 江苏海安,海安市人民医院神经内科
- Keywords:
Acute cerebral infarction;
Alteplase;
Hemorrhagic transformation;
Overall load of small cerebral vascular disease;
Neutrophil-to-lymphocyte ratio;
Risk factors
- From:
Journal of Navy Medicine
2025;46(3):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the status quo and high-risk factors of hemorrhagic transformation(HT)in patients with acute cerebral infarction(ACI)treated with alteplase(rt-PA).Methods A total of 462 patients with ACI who were admitted to Hai'an People's Hospital and treated with rt-PA from June 2019 to June 2023 were retrospectively emrolled.According to the occurrence of HT,the patients were assigned to HT group(n=31)or non-HT group(n=431).The clinical data of the two groups were compared,and high-risk factors of HT in ACI patients treated with rt-PA were analyzed.Results The incidence of HT was 6.71%(31/462).Multivariate logistic analysis showed that increased systolic blood pressure(SBP),severe cerebral small vessel disease(CSVD),and increased neutrophil-to-lymphocyte ratio(NLR)were the high-risk factors of HT in patients with ACI after treatment with rt-PA(P＜0.05).Conclusion There is a high incidence of HT in patients with ACI after treatment with rt-PA,the levels of SBP,CSVD and NLR are the influencing factors,and they can provide a basis for prediction and clinical intervention.
