Relationship between serum SIRT1 and SOX2 levels and liver metastasis one year after colorectal cancer surgery
10.3969/j.issn.1009-0754.2025.02.017
- VernacularTitle:血清SIRT1、SOX2水平与结肠癌术后1年肝转移的关系分析
- Author:
Yanze HUANG
1
;
Yali NIE
Author Information
1. 510000 广东广州,南部战区总医院放射治疗科
- Keywords:
Silent information regulator 1;
Sex determining region Y-box protein 2;
Colon cancer;
Postoperative liver metastasis
- From:
Journal of Navy Medicine
2025;46(2):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of silent information regulator 1(SIRT1)and(sex determining region Y-box protein 2(SOX2)and liver metastasis one year after colorectal cancer surgery.Methods A total of 112 patients who underwent laparoscopic radical operation for colorectal cancer in Southern Theater General Hospital from December 2020 to February 2023 were selected as research objects.Serum SIRT1 and SOX2 levels were detected one day before surgery.Liver metastasis was recorded during one-year follow-up.The patients with liver metastasis were included in the observation group,while patients without liver metastasis were assigned to the control group.The relationship between serum levels of SIRT1 and SOX2 and liver metastasis after colon cancer surgery and the evalution value of both for liver metastasis after surgery in colon cancer patients were analyzed.Results Six patients failed to be followed up,33 patients(31.13%)suffered from liver metastasis one year after surgery(observation group),and the other 73 patients without liver metastasis were included in control group.The observation group had lower SIRT1 and higher SOX2 than the control group(P<0.05).After adjustment of differentiated degree,depth of invasion,and lymph node metastasis,the risk of postoperative liver metastasis in colon cancer patients increased by 1.123 and 1.925 times,respectively(P<0.05),when SIRT1 decreased by 1%and SOX2 increased by 1%,with logit(P)=-1.938-0.754×SIRT1+1.073×SOX2.The area under curve of SIRT1 combined with SOX2 for the evaluation of postoperative liver metastasis in colon cancer patients was greater than SIRT1 and SOX2 alone(Z=2.107,P=0.035;Z=2.481,P=0.013).Conclusion Decreased SIRT1 and increased SOX2 may increase the risk of postoperative liver metastasis in patients with colon cancer.SIRT1 and SOX2 have the potential to serve as predictive indicators for liver metastasis after surgery in colon cancer patients.
